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am630 cb2 receptor antagonist  (Tocris)


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    Tocris am630 cb2 receptor antagonist
    Am630 Cb2 Receptor Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 611 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cb2+receptor+antagonist+am630/AM+630/pm41057773-78-16-80
    Average 96 stars, based on 611 article reviews
    am630 cb2 receptor antagonist - by Bioz Stars, 2026-09
    96/100 stars

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    other:

    Article Title: 2-Arachidonoylglycerol Reduces Proteoglycans and Enhances Remyelination in a Progressive Model of Demyelination
    Article Snippet: In an additional experiment, mice were administered the CB1 receptor antagonist AM251 (2 mg/kg, i.p., Tocris Bioscience) or the CB2 receptor antagonist AM630 (2 mg/kg, i.p., Tocris Bioscience) 30 min before UCM03025 treatment.

    Article Title: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways.
    Article Snippet: Neuroinflammation is closely related to the pathogenesis of neurodegenerative diseases.. Activation of microglia, the resident immune cells in CNS, induces inflammatory responses, resulting in the release of neurotoxic molecules, which favors neuronal death and neurodegeneration.. Nuclear receptor-related 1 (Nurr1) protein, one of the orphan nuclear receptor superfamilies, is an emerging target for neuroprotective therapy.

    Injection:

    Article Title: Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.
    Article Snippet: Cannabinoids have emerged as promising neuroprotective agents due to their capability to activate specific targets, which are involved in the control of neuronal homeostasis and survival.. Specifically, those ligands that selectively target and activate the CB2 receptor may be useful for their anti-inflammatory and neuroprotective properties in various neurological disorders, with the advantage of being devoid of psychotropic effects associated with the activation of CB1 receptors.. The aim of this work has been to investigate the neuroprotective properties of 7-(1,1dimethylheptyl)-4,4-dimethyl-9-methoxychromeno[3,4-d]isoxazole (PM226), a compound derived from a series of chromeno-isoxazoles and -pyrazoles, which seems to have a promising profile related to the CB2 receptor.

    Article Title: The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling.
    Article Snippet: Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation.. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties in various brain disorders.. The anti-inflammatory action of WIN 55,212-2 is potentially associated with driving microglial M2 polarization.

    Control:

    Article Title: The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling.
    Article Snippet: Delayed neurologic sequelae (DNS) are among the most serious complications of carbon monoxide (CO) poisoning caused partly by elevated neuroinflammation.. WIN 55,212-2, a non-selective agonist of cannabinoid receptors, has been demonstrated to have anti-inflammatory properties in various brain disorders.. The anti-inflammatory action of WIN 55,212-2 is potentially associated with driving microglial M2 polarization.



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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.
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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing

    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing